摘要：目的 检测乳腺癌特异性基因1(BCSG1)在化疗以及手术前后乳腺癌患者血液中mRNA的表达差异,并以此来评价BCSG1在乳腺癌治疗疗效评价中的意义.方法 应用逆转录-聚合酶链反应(RT-PCR)检测30例化疗、30例手术前后乳腺癌患者血液中的BCSG1 mRNA表达.结果 化疗以及手术后乳腺癌患者血液中BCSG1 mRNA的表达均有不同程度的降低,并且差异有统计学意义(P值分别为0.041,0.023,均＜0.05).结论 化疗以及手术对乳腺癌的BCSG1 mRNA表达水平有明显影响,BCSG1可以作为乳腺癌治疗疗效评价指标之一. Abstract： Objective To detect the expression of breast cancer special gene 1 (BCSG1)in the blood between the breast cancer patients before operation or neoadjuvant chemotheraphy and after doing that. On the other side, to find out the significance of it on curativing effect in breast cancer. Methods The expression of BCSG1 mRNA was detective by reverse transcription polymerase chain reaction ( RT - PCR)in the blood of 60 breast cancer patients, including pre -neoadjuvant chemotheraphy or operation and post- neoadjuvant chemotheraphy or operation. Results BCSG1 mRNA was detected in 43 of 60 breast cancer patients. There was significant difference between the pre - neoadjuvant chemotheraphy or operation and post - neoadjuvant or operation. The operation and chemotheraphy can decrease the expression of BCSG1 mRNA in the breast cancer patients. Conclusions The gene of BCSG1 may act as a useful marker of breast cancer in curative effect,because it can be affected significantly by neoadjuvant chemotheraphy or operation.

关键词：新辅助化疗 手术前后 乳腺癌患者 血液 bcsg1 

单位：云南省第一人民医院肿瘤外科 昆明 650032 云南省第一人民医院麻醉手术科 昆明 650032