摘要：目的 探讨硒对高碘摄入大鼠甲状腺功能和组织学改变的影响.方法 将wistar大鼠分为对照组、高碘组和高碘加硒组,高碘加硒组灌胃给予亚硒酸钠,观察各组血清甲状腺球蛋白抗体、甲状腺微粒抗体、游离甲状腺原氨酸(FT3)游离甲状腺素(FT4)及促甲状腺激素(TSH)水平,光镜下甲状腺组织学变化.结果 各组实验前后血清FT3、FT4和TSH水平差异无统计学意义(P＞0.05),高碘组两种抗体水平逐渐缓慢升高,自身前后对比差异有统计学意义(P＜0.05),而高碘加硒组抗体水平变化不大(P＞0.05).光镜下高碘组甲状腺滤泡胞腔明显增大,腔内充满了胶质,甚至可以见到滤泡融合现象,与高碘组相比,高碘加硒组甲状腺组织形态趋于正常化.结论 高碘组可诱发类似甲状腺肿的病理学变化,且自身抗体水平随着时间的延长逐步升高,而硒对此有保护作用. Abstract： Objective To investigate the influence of selenium on the function and histio-structure of thyroid of rats with excessive intake of iodine.Methods Wistar rats were divided into three groups by random:normal control, high iodine group, and high iodine plus selenium group.We lavaged rats with sodium selenite in the high iodine plus selenium group.At the end of the experiment, we observed the histio-structure and levels of TGAb, TMAb, FT3, FT4 and TSH in serum.Results The levels of FT3, FT4 and TSH did not change much (P ＞ 0.05), the levels of TGAb and TMAb in the high iodine group grew up slowly (P ＜ 0.05), and did not change much in the high iodine plus selenium group.Under light microscope, the follicle of thyroid of rats grew much larger and follicular epithelial cells were pushed thinner in the high iodine group.Compared with the high iodine group, the follicular of the thyroid in the high iodine plus selenium group was much better.Conclusions The excessive intake of iodine contributes to goiter, and selenium has therapeutic effect on it.

关键词：高碘 wistar大鼠 甲状腺功能 组织学改变 function 

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