摘要：目的 观察短期应用阿托伐他汀对高血压病患者左室舒张功能及C反应蛋白(CRP)的影响.方法 选择高血压病患者87例,分为阿托伐他汀组(49例)及对照组(38例).对照组给予常规降压药物治疗,治疗组在常规治疗基础上加用阿托伐他汀.测定治疗前后二尖瓣舒张早期峰值流速(E)及减速时间(DT)、舒张晚期峰值流速(A)、舒张早期与舒张晚期峰值流速之比(E/A)、等容舒张时间(IVRT)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)及CRP的水平.结果 治疗12周后治疗组与治疗前比较差异有统计学意义(P＜0.05),E峰增高,A峰降低,E/A比值增加,IVRT缩短,DT缩短(P＜0.05),与对照组比较差异均有统计学意义(P＜0.05).治疗组CRP、LDL-C、TC水平较治疗前显著降低(P＜0.05),与对照组比较差异有统计学意义(P＜0.05).治疗前后治疗组TC、LDL-C水平与E/A均无相关性(P＞0.05).结论 短期应用阿托伐他汀可降低高血压病患者CRP水平,改善左室舒张功能. Abstract： Objective To observe the effects of atorvastatin on C - reactive protein and left ventricular diastolic function in patients with essential hypertension.Methods Eighty - seven patients with essential hypertension were randomly divided into two groups, including control group and atorvastatin group.The control group was treated with normal therapy, whereas atorvastatin group was treated with normal therapy and atorvastatin.The early filling velocity of the E wave, peak A wave velocity, E/A ratio, isovolumic relaxation time(IVRT), DT, LDL - C, TC and CRP were observed before and after treatment.Results Compared with the control group, peak E wave velocity of atorvastatin group was increased,peak A wave velocity decreased, E/A ratio increased, IVRT and DT shortened, the level of LDL -C ,TC and CRP decreased(P ＜0.05).Before and after treatment of atorvastatin group there was no correlationship between the level of LDL - C, TC and CRP and E/A.Conclusions Short - term application of

关键词：阿托伐他汀 高血压病患者 左室舒张功能 反应蛋白 essential 

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