摘要：目的 探讨血管内皮生长因子-C(VEGF-C)和sonic hedgehog(SHH)在食管鳞状细胞癌(ESCC)组织中的表达及其与淋巴结转移的关系.方法 应用免疫组织化学法检测40例ESCC组织和30例癌旁正常黏膜组织中VEGF-C及SHH的表达.结果 40例ESCC组织中25例(62.5%)出现VEGF-C阳性,24例(60.0%)出现SHH阳性;癌旁正常食管黏膜组织30例中仅5例(16.7%)出现VEGF-C阳性,8例(26.7%)出现SHH阳性,其差异均有统计学意义(P＜0.05).在VEGF-C阳性的25例ESCC组织中19例出现淋巴结转移,而在VEGF-C阴性的15例ESCC组织中仅2例出现淋巴结转移,其差异有统计学意义(P＜0.05);SHH表达阳性的24例ESCC中18例有淋巴结转移,而SHH表达阴性的16例ESCC中7例有淋巴结转移,其差异有统计学意义(P＜0.05).结论 VEGF-C和SHH参与了ECSS的发生发展,且与其淋巴结转移的发生有关.对于VEGF-C及SHH表达阳性的ESCC患者,术前和术中应分别加强对淋巴结转移的评估及清扫,以提高其生存率. Abstract： Objective To study the expression of vascular endothelial growth factor-C(VEGF-C)and sonic hedgehog(SHH) in esophageal squamous cell carcinoma(ESSC)and explore the relationship between lymph node metastasis of ESCC and them.Methods The expression of VEGF-C and SHH was detectde using immunohistochemical method on 40 specimens from patients with ESSC and 30 cases of non-cancerous esophageal tissues. Results In the 40 specimens from patients with ESSC, 25 cases(62.5%) were VEGF-C positive,24 cases(60.0%)were SHH positive. In 30 cases of non-cancerous esophageal tissues,only 5 cases(16.7%)were VEGF-C positive,8 cases(26.7%)were SHH positive,there were both significant differences between the 2 types of tissues (P＜0.05).There were 19 cases had lymph node metastasis in the 25 cases whose VEGF-C were positive,while only 2 cases had lymph node metastasis in the 15 cases whose VEGF-C were negative (P＜0.05). There were 18 cases had lymph node metastasis in the 24 cases whose SHH were positive,while o

关键词：血管内皮生长因子 sonic hedgehog 食管鳞状细胞癌 表达阳性 

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