摘要：目的 探讨卵巢上皮性癌组织中人表皮生长因子受体(HER)-2/neu(c-erbB-2)的过表达及其与卵巢上皮性癌患者预后的关系.方法 采用免疫组化染色法检测77例卵巢上皮性癌组织中HER-2/neu的过表达,分析其与卵巢上皮性癌临床病理因素和生存时间之间的相关性.结果 卵巢上皮性癌组织中HER-2/neu的过表达率为28.6%.单因素分析显示,HER-2/neu过表达阳性患者的中位生存时间(25.7个月)明显短于HER-2/neu过表达阴性者(>34.1个月,P＝0.001).多因素分析显示, HER-2/neu过表达是影响患者预后的独立因素(P＝0.032).结论 HER-2/neu过表达在卵巢上皮性癌的发生和进展中起重要作用,是影响患者预后的独立危险因素. Abstract： Objective To investigate the overexpression of HER-2/neu(c-erbB-2) in epithelial ovarian cancer and the relationship between HER-2/neu overexpression and its prognostic significance. Methods The overexpression of HER-2/neu was detected by immunohistochemistry in 77 ovarian carcionma. Correlations between HER-2/neu overexpression and clinicopathologic features and survival time of epithelial ovarian cancer were analyzed. Results The overexpression rate of HER-2/neu in epithelial ovarian carcionma was 28.6%. In univariate analysis, significant difference in median survival time was observed between HER-2/neu overexpression patients and HER-2/neu expression negative patients(P＝0.001). In multivariate analysis, HER-2/neu overexpression was an independent prognostic factor of epithelial ovarian cancer(P＝0.032).Conclusions HER-2/neu overexpression plays an important role in the genesis and progression of epithelial ovarian carcionma. It is an independent prognostic factor of ovarian carcinoma.

关键词：人表皮生长因子受体 卵巢上皮性癌 上皮性癌组织 过表达 预后价值 

单位：河南省郑州市中心医院妇产科 450007 天津医科大学总医院妇产科