摘要：目的 观察培美曲塞二钠联合顺铂治疗晚期非鳞非小细胞肺癌患者的近期临床疗效和毒性反应.方法 20例Ⅲb～Ⅳ期非鳞非小细胞肺癌患者均经病理组织学和(或)细胞学检查确诊.培美曲塞二钠联合顺铂治疗2个周期后评价疗效.结果 20例患者均可评价,获得完全缓解(CR)0例,部分缓解(PR)9例,有效率为45.0%(9/20).最主要的不良反应为骨髓抑制,但均可耐受.结论 培美曲塞二钠联合顺铂治疗晚期非鳞非小细胞肺癌有较好疗效,不良反应轻,易于耐受. Abstract： Objective To observe the clinical efficacy and adverse effect of pemetrexed disodium combined with cisplatin in treating advanced non-small cell lung cancer of nonsquamous cell histology. Methods A total of 20 patients with advanced non-small cell lung cancer of nonsquamous cell histology diagnosed by pathology or cytology were enrolled into the study.The patients were treated with pemetrexed disodium and cisplatin. Each patient was received 2 cycles chemotherapy at least. The short-term effect,side effects were evaluated after chemotherapy. Results Complete remission (CR)was observed in 0 case and PR in 9 cases.The response rate(RR) was 45.5% (9/20).The main side effects were bone marrow suppression,but that was tolerable. Conclusions The regimen of pemetrexed disodium combined with cisplatin is effective,safe and well tolerable in the treatment of non-small cell lung cancer of nonsquamous cell histology.

单位：江苏省无锡市滨湖区中医院 214121 南京医科大学第三附属医院肿瘤血液科