摘要：目的 通过对子宫内膜浆液性乳头状癌(UPSC)的临床及病理特征的分析,探讨其合理的治疗方法.方法 自2002年6月至2008年12月我院收治子宫内膜浆液性乳头状癌患者23例,对其临床病理、诊断方法、治疗方法及预后进行回顾性分析.结果 全部患者病例采用手术治疗,术后辅助放疗和(或)化疗者17例.Ⅲ、Ⅳ期患者占56.5%,52.2%的患者肌层浸润深度超过1/2肌层(12/23),52.2%有子宫外扩散(12/23),腹膜后淋巴结转移率为54.5%(6/11),86.6%患者雌孕激素受体阴性.预后差,随访期内12例死亡.结论 UPSC少见,临床诊断困难,依靠病理学检查可以确诊.子宫内膜浆液性乳头状癌有其独特的临床病理特征,与普通的子宫内膜癌明显不同,肿瘤高度恶性,预后差,合理的个体化综合治疗可延长生存期. Abstract： Objective To study the rational therapy for uterine papillary serous carcinoma (UPSC) and analyze its clinical and pathologic features. Methods A retrospective study was conducted on incidence, clinical characteristics,pathological feature,diagnosis and treatment,prognosis of 23 patients with UPSC,who was admitted in our hospital from January 2000 to June 2006.Results All the patients underwent operation, and 17 cases received postoperative radiotherapy and(or) chemotherapy. Among all the patients with UPSC,56.5% was stage Ⅲ and Ⅳ;52.2% with deep myometrial invasion;Estrogen or progestin receptors were negative in 86.6% cases.12 cases died during the follow ing up period, indicating poor prognosis.Conclusions UPSC is an uncommon tumor. It is difficult to make the diagnosis for clinicians.UPSC can be surely diagnosed with clinical pathology.The clinical and pathologic features of UPSC are different from the common endometrial carcinoma. Rational individu alized treatment can prolong survival time.

关键词：子宫内膜癌 浆液性乳头状癌 临床与病理分析 carcinoma 患者 

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