摘要：目的 改良急性重度有机磷农药中毒(AOPP)的治疗方法.方法 将我院2005年1月至2008年12月收治的48例重度AOPP患者随机分为两组,对照组按常规洗胃、阿托品、复能剂、保肝、利尿治疗,观察组在此基础上加用树脂罐血液灌流(HP)治疗,并在围术期应用中药生大黄导泻排毒及输注新鲜冰冻血浆,分别对神志恢复时间、阿托品总用量、胆碱酯酶复活时间、胆碱酯酶(ChE)恢复达50%的时间,并发症(农药中毒反跳、中间综合征、多脏器损害、多脏器衰竭、迟发性神经损害)发生率和治愈率、病死率进行监测.结果 观察组较对照组阿托品用量少(t=4.35,P＜0.01),意识恢复快(t=3.61,P＜0.01),ChE恢复50%的时间快(t=2.94,P＜0.01),治愈率高(96.0%vs65.2%,χ2=5.57,P＜0.05＝,病死率低(4.0%vs 34.8%,χ2=5.57,P＜0.05).结论 HP治疗并在围术期应用中药生大黄导泻排毒及输注新鲜冰冻血浆的方法能迅速清除体内毒物,减少并发症,提高急性重度AOPP的治愈率. Abstract： Objective To improve the treatment of acute severe organophosphorus pesticide poisoning(AOPP).Methods The 48 cases of severe AOPP patients were randomly divided into two groups, control group(n = 23)according to conventional gastric lavage, atropine, rehabilitation can be agents, liver,diuretic treatment, the observation group in this basis can increase resin hemoperfusion treatment and application in perioperative medicine detoxification catharsis rhubarb and fresh frozen plasma infusion.Results The observation group with less atropine than in control group(t =4.35, P ＜0.01), awareness and rapid recovery(t =3.61, P ＜0.01), ChE time to restore 50% faster(t =2.94, P ＜ 0.01), a high cure rate (96.0% vs 65.2% , χ2 =5.57, P ＜ 0.05＝, low mortality(4.0% vs 34.8%, χ2 =5.57, P ＜0.05).Conclusions This therapy method can poison the body quickly cleared to reduce the complications of severe acute AOPP,and to improve cure rate.

关键词：血液灌流 抢救 重度有机磷农药中毒 疗效研究 treatment 

单位：广东省阳江市人民医院急诊科 529500 广东省阳江市人民医院内科 529500