摘要：目的 观察瑞舒伐他汀对急性脑梗死患者疗效及脑梗死体积变化的影响.方法 将100例急性脑梗死患者随机分为观察组52例和对照组48例,对照组患者入院后均给予常规治疗方法,观察组在对照组治疗的基础上加服瑞舒伐他汀20 mg/d.两组均连续治疗30 d.检测两组患者神经功能缺损程度评分和脑梗死灶体积.结果 治疗后观察组梗死灶体积显著低于治疗前及对照组(P均＜0.05);观察组患者神经功能缺损程度评分低于对照组(P＜0.01),Barthel指数高于对照组(P＜0.01);观察组总有效率显著高于对照组(P＜0.05).瑞舒伐他汀不良反应轻微.结论 瑞舒伐他汀能加速脑梗死患者神经功能的恢复,可缩小脑梗死体积,有保护神经的作用. Abstract： Objective To observe the effect of rosuvastatin on efficacy and volume changes of cerebral infarction in patients with acute cerebral infarction. Methods One hundred patients with acute cerebral infarction were randomly divided into observe group (52 cases) and control group (48 cases). The control group were given conventional treatment after admission, the observe group were given rosuvastatin(20 mg/day) treatment on the basis of conventional treatment.Both groups were treated for 30 days. Neurological deficit scores and infarct volumes of two groups were recorded. Results After treatment, the infarct volume of the observe group was significantly lower than before treatment and the control group(P all＜0.05),the neurologic impairment score of the observe group was lower than the control group(P＜0.01),the Barthel index of the observe group was higher than the control group(P＜0.01),the total effective rate of the observe group was significantly higher than the control group (P＜0.05). The side effects of rosuvast were minor. Conclusions Rosuvastatin can accelerate the recovery of neurological function in patients with cerebral infarction, can reduce infarct size and has the effect of nerve protection.

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