摘要：目的 探讨镇静剂(咪达唑仑)和肌松剂(维库溴铵)联合氧驱动雾化吸入布地奈德治疗儿童重症哮喘的临床疗效及对患儿肺功能的影响.方法 将86例重症哮喘患儿随机分为两组,观察组45例,采用咪达唑仑与维库溴铵联合氧驱动雾化吸入布地奈德治疗;对照组41例,单独采用布地奈德治疗.结果 观察组的总有效率明显高于对照组,两组比较差异有统计学意义(P＜0.05).观察组咳嗽消失、喘息消失及哮鸣音消失时间均明显短于对照组,差异均有统计学意义(P＜0.05).对照组治疗后第1秒用力呼气量(FEV1)、第1秒用力呼气量占用力肺活量的百分比(FEV1%)与治疗前比较差异无统计学意义(P＞0.05).观察组治疗后FEV1、FEV1都较治疗前明显升高,差异有统计学意义(P＜0.05);并且观察组FEV1、FEV1%都较对照组升高明显,差异有统计学意义(P＜0.05).结论 咪达唑仑、维库溴铵联合氧驱动雾化吸入布地奈德治疗哮喘的疗效显著,肺功能状态改善明显,不良反应少,是治疗儿童重症哮喘的有效方法. Abstract： Objective To discuss the clinical effect of midazolam,vearonium,vecuronium combined oxygen-driren buaesonide inhalation in treating the children with severe asthma and the influence to lung function of the children.Methods The 86 cases of the children with severe asthma were divided into observation group(n=45) and control group (n=41). The obserration group was treated by midazolm,vecuronicum combined oxygen-driren budesoniae of midazolam,control group was treated by budesonide individually. Results The total effective of observation group was higher than that of the control group (P＜0.05). The disappearance of cough,asthma and wheeze was shortter than control group (P＜0.05). There was no significant difference in the FEV1 and FEV1% of control group between before and after treatment (P＞0.05). After treatment,the FEV1 and FEV1% in the treatment group was higher than before treatment and that of c

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